Role of polymeric immunoglobulin receptor in the metastasis, growth, diagnosis, and treatment of hepatocellular carcinoma / 临床肝胆病杂志

ABSTRACT

Chronic inflammation of the liver is a risk factor that promotes the progression of hepatocellular carcinoma, and in the presence of viral infection, enhanced Fc receptor signal will further aggravate inflammatory response and participate in the process of canceration. Polymeric immunoglobulin receptor (pIgR) not only plays a critical role in first-line anti-infection immunity, but also promotes the metastasis and growth of early-stage hepatocellular carcinoma. Identifying pIgR as a predictive index for metastatic potential in patients with early-stage liver cancer can help to promote the stratification and treatment decisions for such patients, which has a positive significance in improving patient prognosis. Targeted inhibition of the pIgR/Yes signal cascade as a potential treatment option may provide more treatment options for controlling tumor size to allow resection or transplantation.