Transforming growth factor-β signaling pathway and targeted therapy in ovarian cancer / 国际肿瘤学杂志

ABSTRACT

The transforming growth factor-β (TGF-β) is a polypeptide cytokine,belonging to the TGF-β superfamily.TGF-β signaling pathway can regulate cell biological activity and play a bidirectional regulatory role in the development and progression of cancer.TGF-β signaling pathway can cause the occurrence and development of ovarian cancer through various processes including inducing cell excessive proliferation,influencing tumor microenvironment and regulating immune evasion.Targeted therapy with TGF-β as a biomarker for ovarian cancer provides a new way to improve the prognosis of patients.