MYC inhibition associated mechanism research of Group3 medulloblastoma / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 613-616, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-823565
ABSTRACT
Medulloblastoma (MB)is the most prevalent pediatric brain tumor. Group3 MB is the most malignant subgroup,quiet a part of which are MYC-amplified. Blocking the upstream gene sites of MYC is mainly achieved through the blockade of miR-494,DDX3,NOTCH1 pathway;BETi or ATR/ Chk1 double-inhi-bition realizes the inhibition of duplication or transcription of MYC;as to the blockade of downstream genes of MYC,researchers mainly focus on LDHA,SETD8 and EZH2. All of these researches which target on MYC-amplified associated anti-tumor treatment mechanism present the theoretical basis for anti-MYC-associated medulloblastoma clinically.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of International Oncology
Année:
2019
Type:
Article
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