Clinical study of Chaihu-Longgu-Muli decotion combined with western medicine in the treatment of somatic anxiety disorder / 国际中医中药杂志

ABSTRACT

Objective To evaluate the therapeutic effect of Chaihu-Longgu-Muli decotion combined with western medicine in the treatment of somatic anxiety disorder. Methods A total of 93 patients with somatic anxiety were divided into control group (46 cases) and study group (47 cases) according to random number table method. The control group was treated with conventional western medicine. The study group was treated with Chaihu-Longgu-Muli decotion on the basis of the control group. The two groups were treated for 4 weeks. Before and after treatment, TCM syndrome scores were conducted. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality. The Self-rating Anxiety Scale (SAS) was used to evaluate anxiety. The adverse reaction was recorded and clinical efficacy was evaluated. Results The total effective rate of the study group was 93.62% (44/47), 67.39% (31/46) of the control group, and the difference was statistically significant between the two groups (χ2=10.244, P=0.001). After treatment, insomnia, limb chills, palpitation, limb burnout, limb pain scores in the study group were significantly lower than those of the control group (t values were 4.190, 4.707, 4.714, 3.686, 7.070, respectively, all Ps<0.01). After treatment, the scores of PSQI (9.4 ± 3.2 vs. 13.8 ± 3.8, t=6.045) and SAS (48.7 ± 13.7 vs. 58.1 ± 12.9, t=3.405) in the study group were significantly lower than those in the control group (P<0.01). During the treatment, the incidence of adverse reactions was 19.6% (9/46) in the control group and 4.3% (2/47) in the study group. The difference between the two groups was statistically significant ( χ 2=5.225, P=0.022). Conclusions The Chaihu-Longgu-Muli decotion combined with western medicine can improve the symptoms of traditional Chinese medicine, sleep quality and anxiety of patients with somatic anxiety, reduce adverse reactions and improve the clinical efficacy.