Effects of different hemoglobin concentrations on lung injury in a rabbit model of hemorrhagic shock and resuscitation / 中华麻醉学杂志
Chinese Journal of Anesthesiology
; (12): 1233-1236, 2019.
Article
Dans Zh
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| ID: wpr-824696
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ABSTRACT
Objective To evaluate the effect of different hemoglobin(Hb)concentrations on the lung injury in a rabbit model of hemorrhagic shock and resuscitation(HS-R).Methods Fifty healthy male New Zealand rabbits,aged 2 months,weighing 1.9-2.4 kg,were divided into 5 groups(n=10 each)u-sing a random number table method: control group(group C),HS-R group(group H),and three HS-R plus infusion of concentrated red blood cell groups group R1(60 g/L≤Hb<80 g/L),group R2(80 g/L≤Hb<100 g/L)and group R3(100 g/L≤Hb<120 g/L).The animals were sacrificed at 3 h after resuscita-tion,lung tissues were obtained for examination of the pathological changes with a light microscope,and lung tissues were obtained again for determination of wet to dry weight ratio(W/D ratio),neutrophil my-eloperoxidase(MPO),NO level and cell apoptosis(by TUNEL).Results Compared with group C,the levels of MAP and NO,W/D ratio and apoptosis index were significantly increased in the other groups(P<0.05).Compared with group H,the levels of MAP and NO,W/D ratio and apoptosis index were signifi-cantly decreased in R2 and R3 groups(P<0.05).Compared with group R2,the apoptosis index was signif-icantly increased at T5(P<0.05),and no significant change was found in the other parameters in group R3(P>0.05).Conclusion Maintaining Hb 80-100 g/L after HS-R reduces acute lung injury in rabbits.
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Chinese Journal of Anesthesiology
Année:
2019
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Article