Risk Factors of Acute Kidney Injury Complicating Adult Primary Nephrotic Syndrome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 436-443, 2020.
Article
Dans Zh
| WPRIM
| ID: wpr-826342
Responsable en Bibliothèque :
WPRO
ABSTRACT
To explore the risk factors of acute kidney injury(AKI)in adult primary nephrotic syndrome(PNS). Totally 185 patients with PNS were divided into AKI group(=51)and non-AKI group(=134).The demographic data and clinical and histological features at admission were compared between the two groups.The independent risk factors for AKI were evaluated by Logistics regression analysis. In 51 PNS patients with AKI,the common pathological types of AKI included minor glomerular abnormalities(29.4%),IgA nephropathy(25.5%),and membranous nephropathy(17.6%).The incidences of renal tubular casts and epithelial vacuoles in the AKI group were significantly higher than those in the non-AKI group(=0.004,=0.030).Males were more likely to suffer from AKI than females(=0.000).Patients in AKI group had significantly lower albumin level(=0.015)and higher levels of random urine protein,serum creatinine,uric acid,urea nitrogen,and triglyceride than non-AKI group(=0.030,=0.000,=0.000,=0.000,and =0.006),and polyserous and oliguria occurred more often in the AKI group(=0.000,=0.002).The AKI group had significantly higher incidences of high blood pressure and infections(=0.035,=0.000).Multivariate logistics regression analysis showed albumin(96 μmol/L),urea nitrogen(≥6.8 mmol/L),uric acid(≥400 μmol/L),diabetes,infection,and renal tubular casts were the independent risk factors for AKI. AKI complicating PNS is associated with a variety of factors.Its independent risk factors include the levles of albumin,serum creatinine,urea nitrogen,and uric acid,diabetes,infections,and renal tubular casts.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Facteurs de risque
/
Créatinine
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Atteinte rénale aigüe
/
Rein
/
Syndrome néphrotique
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites du sujet:
Adult
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Female
/
Humans
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Male
langue:
Zh
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2020
Type:
Article