The value of combined use of chromosomal karyotyping and chromosome microarray analysis for prenatal diagnosis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 392-396, 2020.
Article
de Zh
| WPRIM
| ID: wpr-828317
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To assess the value of combined chromosomal karyotyping and chromosomal microarray analysis (CMA) for prenatal diagnosis.@*METHODS@#G-banding karyotyping and CMA were simultaneously performed on 546 women who were subjected to amniocentesis during middle pregnancy.@*RESULTS@#In total 82 cases were detected with chromosomal abnormalities. The two methods were consistent in 43 cases, which included 14 trisomy 21, 6 trisomy 18, 1 trisomy 13, 14 sex chromosomal aneuploidies, 4 chromosomal deletions, 3 chromosomal duplications and 1 sex chromosomal mosaicism. Fifteen fetuses with chromosomal abnormalities detected by CMA were missed by karyotyping analysis, which included 9 microdeletions and 6 microduplications. Sixteen fetuses with chromosomal abnormalities detected by karyotyping analysis were missed by CMA, which included 15 chromosomal translocations and 1 sex chromosomal mosaicism. In 7 cases, the results of karyotyping analysis and CMA were inconsistent. One supernumerary marker chromosome detected by karyotyping analysis was verified by CMA as 9p13.1p21.1 duplication.@*CONCLUSION@#Combined chromosomal karyotyping and CMA can significantly improve the detection rate for chromosomal abnormalities, which has a great value for prenatal diagnosis.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Diagnostic prénatal
/
Aberrations des chromosomes
/
Maladies chromosomiques
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Analyse sur microréseau
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Diagnostic
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Génétique
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Caryotypage
Type d'étude:
Diagnostic_studies
Limites du sujet:
Female
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Humans
/
Pregnancy
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2020
Type:
Article