Clinical Neuropathological Analysis of 10 Cases of Cerebral Amyloid Angiopathy-Related Cerebral Lobar Hemorrhage
Journal of Korean Neurosurgical Society
;
: 30-35, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-83157
ABSTRACT
OBJECTIVE:
The clinical and pathological characteristics of 10 cases of cerebral amyloid angiopathy (CAA)-related cerebral lobar hemorrhage (CLH) that was diagnosed at autopsy were investigated to facilitate the diagnosis of this condition.METHODS:
The clinical characteristics of 10 cases of CAA-related CLH were retrospectively reviewed, and a neuropathological examination was performed on autopsy samples.RESULTS:
The 10 cases included two with a single lobar hemorrhage and eight with multifocal lobar hemorrhages. In all of the cases, the hemorrhage bled into the subarachnoid space. Pathological examinations of the 10 cases revealed microaneurysms in two, double barrel-like changes in four, multifocal arteriolar clusters in five, obliterative onion skin-like intimal changes in four, fibrinoid necrosis of the vessels in seven, neurofibrillary tangles in eight, and senile plaques in five cases.CONCLUSION:
CAA-related CLHs were located primarily in the parietal, temporal, and occipital lobes. These hemorrhages normally consisted of multiple repeated CLHs that frequently bled into the subarachnoid space. CAA-associated microvascular lesions may be the pathological factor underlying CLH.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Autopsie
/
Espace sous-arachnoïdien
/
Études rétrospectives
/
Enchevêtrements neurofibrillaires
/
Angiopathie amyloïde cérébrale
/
Plaque amyloïde
/
Oignons
/
Diagnostic
/
Rabéprazole
/
Hémorragie
Type d'étude:
Etude diagnostique
/
Étude observationnelle
langue:
Anglais
Texte intégral:
Journal of Korean Neurosurgical Society
Année:
2015
Type:
Article
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