Hemodynamic alterations in cirrhosis and portal hypertension / 대한간학회지
The Korean Journal of Hepatology
;
: 347-352, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-8336
ABSTRACT
Portal hypertension (PHT) is associated with hemodynamic changes in intrahepatic, systemic, and portosystemic collateral circulation. Increased intrahepatic resistance and hyperdynamic circulatory alterations with expansion of collateral circulation play a central role in the pathogenesis of PHT. PHT is also characterized by changes in vascular structure, termed vascular remodeling, which is an adaptive response of the vessel wall that occurs in response to chronic changes in the environment such as shear stress. Angiogenesis, the formation of new blood vessels, also occurs with PHT related in particular to the expansion of portosystemic collateral circulation. The complementary processes of vasoreactivity, vascular remodeling, and angiogenesis represent important targets for the treatment of portal hypertension. Systemic and splanchnic vasodilatation can induce hyperdynamic circulation which is related with multi-organ failure such as hepatorenal syndrome and cirrhotic cadiomyopathy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Circulation splanchnique
/
Circulation collatérale
/
Cellules endothéliales
/
Cellules étoilées du foie
/
Hémodynamique
/
Hypertension portale
/
Circulation hépatique
/
Cirrhose du foie
langue:
Anglais
Texte intégral:
The Korean Journal of Hepatology
Année:
2010
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS