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Collateral Ventilation Quantification Using Xenon-Enhanced Dynamic Dual-Energy CT: Differences between Canine and Swine Models of Bronchial Occlusion
Korean Journal of Radiology ; : 648-656, 2015.
Article Dans Anglais | WPRIM | ID: wpr-83659
ABSTRACT

OBJECTIVE:

The aim of this study was to evaluate whether the difference in the degree of collateral ventilation between canine and swine models of bronchial obstruction could be detected by using xenon-enhanced dynamic dual-energy CT. MATERIALS AND

METHODS:

Eight mongrel dogs and six pigs underwent dynamic dual-energy scanning of 64-slice dual-source CT at 12-second interval for 2-minute wash-in period (60% xenon) and at 24-second interval for 3-minute wash-out period with segmental bronchus occluded. Ventilation parameters of magnitude (A value), maximal slope, velocity (K value), and time-to-peak (TTP) enhancement were calculated from dynamic xenon maps using exponential function of Kety model.

RESULTS:

A larger difference in A value between parenchyma was observed in pigs than in dogs (absolute difference, -33.0 +/- 5.0 Hounsfield units [HU] vs. -2.8 +/- 7.1 HU, p = 0.001; normalized percentage difference, -79.8 +/- 1.8% vs. -5.4 +/- 16.4%, p = 0.0007). Mean maximal slopes in both periods in the occluded parenchyma only decreased in pigs (all p < 0.05). K values of both periods were not different (p = 0.892) in dogs. However, a significant (p = 0.027) difference was found in pigs in the wash-in period. TTP was delayed in the occluded parenchyma in pigs (p = 0.013) but not in dogs (p = 0.892).

CONCLUSION:

Xenon-ventilation CT allows the quantification of collateral ventilation and detection of differences between canine and swine models of bronchial obstruction.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Respiration / Suidae / Xénon / Maladies des bronches / Bronchographie / Ventilation pulmonaire / Tomodensitométrie hélicoïdale / Obstruction des voies aériennes / Modèles animaux de maladie humaine Limites du sujet: Animaux langue: Anglais Texte intégral: Korean Journal of Radiology Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Respiration / Suidae / Xénon / Maladies des bronches / Bronchographie / Ventilation pulmonaire / Tomodensitométrie hélicoïdale / Obstruction des voies aériennes / Modèles animaux de maladie humaine Limites du sujet: Animaux langue: Anglais Texte intégral: Korean Journal of Radiology Année: 2015 Type: Article