Evaluation of antibacterial effect and short-term clinical effect of new triple antibiotic paste against Enterococcus faecalis for root canal retreatment / 第二军医大学学报

ABSTRACT

Objective: To compare the antibacterial effect and short-term clinical effect of new triple antibiotic paste (ornidazole, ciprofloxacin and minocycline) used alone and in combination with calcium hydroxide paste against Enterococcus faecalis in root canal retreatment. Methods: A total of 149 single rooted teeth with failed endodontic treatment were selected in the present study. The samples were randomly divided into 5 groups: calcium hydroxide paste group (CH group), triple antibiotic paste (metronidazole, ciprofloxacin and minocycline) group (TAP group), new triple antibiotic paste group (NTAP group), the combination group of calcium hydroxide paste and new triple antibiotic paste (CH+NTAP group), and camphor phenol group (CP group). After removal of the root-flling material, the quantities of Enterococcus faecalis in the root canals were determined before and after root canal preparation and 7 d after root dressing. The short-term clinical effects were evaluated 7 d after root dressing in each group. Results: After root canal preparation and root dressing of 7 d, the quantities of Enterococcus faecalis in root canals in each group were significantly decreased versus before root canal preparation (all P0.05). Conclusion: Calcium hydroxide paste and triple antibiotic paste alone or in combination have better antibacterial effect for root canal disinfection against Enterococcus faecalis in root canal retreatment. They also have better short-term clinical effect, especially the new triple antibiotic paste, which can be considered as an effective alternative intracanal medicament and is worthy of clinical application.