Bladder neoplasms in patients aged between 20 and 30 years old: An analysis of clinical characteristics / 第二军医大学学报

ABSTRACT

Objective To evaluate the clinicopathological features and prognosis of patients with bladder neoplasm aged between 20 and 30 years old. Methods The clinical data of the patients with bladder tumors aged 20-30 years old, who were treated from Jan. 2009 to March 2014, were retrospectively analyzed. The general information, clinical manifestations, diagnostic essentials, pathological outcomes, treatment strategies and prognoses were analyzed. Results A total of 20 patients were included in this study, which accounted for 1.22%(20/1 645) of all the bladder neoplasm cases in our hospital during the same period. The mean age of the 20 patients was (25.8±3.1) years old, including 13 males and 7 females. Gross hematuria as the main clinical symptoms were found in 10 patients, 6 patients were detected accidently due to non-hematuria symptoms, and 4 patients were diagnosed during the health checkup. There were 2 multifocal and 18 solitary tumors, with the total number of tumors being 24, including 15 in the lateral bladder wall, 3 in the posterior wall, 1 in the anterior wall, 3 in the trigone and 2 in the bladder neck. Two tumors in patients with hematuria were missed by ultrasound. The maximum diameters of tumors measured by ultrasound ranged from 0.4 cm to 2.7 cm (mean [1.1±0.7] cm). The detection rate of cystoscopy for tumors was 100%. The pathological results found 1 paraganglioma and 19 urothelial neoplasms, including 2 urothelial flat lesions and 17 papillary urothelial neoplasms. Of the 20 patients, 19 received transurethral resection of bladder tumor, 1 underwent exploratory laparotomy after four-cycles of neoadjuvant chemotherapy with gemcitabine and cisplatin. Sixteen patients were followed-up for 3 months to 5 years (mean [28±16] months). Three patients had recurrence, with one progressed to muscle invasive carcinoma. Conclusion Bladder neoplasms in patients aged 20-30 years old are usually solitary, of low grade and low stage; meanwhile, there is a possibility of highly aggressive disease. It is noteworthy that a good few of patients are asymptomatic. The long-term follow-up is crucial for all these patients.