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Luteolin 5-O-glucoside from Korean Milk Thistle, Cirsium maackii, Exhibits Anti-Inflammatory Activity via Activation of the Nrf2/HO-1 Pathway
Natural Product Sciences ; : 183-191, 2017.
Article Dans Anglais | WPRIM | ID: wpr-83907
ABSTRACT
Luteolin 5-O-glucoside is the major flavonoid from Korean thistle, Cirsium maackii. We previously reported the anti-inflammatory activities of luteolin 5-O-glucoside in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. In this study, we determined the anti-inflammatory mechanisms of luteolin 5-O-glucoside through the inhibition of nitric oxide (NO) production in vitro and in vivo. Results revealed that luteolin 5-O-glucoside dose-dependently inhibited NO production and expression of iNOS and COX-2 in LPS-induced RAW 264.7 cells. Luteolin 5-O-glucoside also significantly inhibited the translocation of NF-κB, the activation of MAPKs, and ROS generation in LPS-induced RAW 264.7 cells. In addition, protein expressions of Nrf-2 and HO-1 were also upregulated by luteolin 5-O-glucoside treatment. Moreover, luteolin 5-O-glucoside inhibited λ-carrageenan-induced mouse paw edema by 65.34% and 48.31% at doses of 50 and 100 mg/kg body weight, respectively. These findings indicate potential anti-inflammatory effect of luteolin 5-O-glucoside particularly by downregulating NF-κB and upregulating HO-1/Nrf-2 pathway.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Poids / Techniques in vitro / Silybium marianum / Cirsium / Lait / Lutéoline / Oedème / Monoxyde d'azote Limites du sujet: Animaux langue: Anglais Texte intégral: Natural Product Sciences Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Poids / Techniques in vitro / Silybium marianum / Cirsium / Lait / Lutéoline / Oedème / Monoxyde d'azote Limites du sujet: Animaux langue: Anglais Texte intégral: Natural Product Sciences Année: 2017 Type: Article