Effect of lidocaine aerosol on cardiovascular response and postoperative sore throat, hoarseness in patients receiving double lumen tube intubation / 第二军医大学学报

ABSTRACT

Objective: To observe the effect of lidocaine aerosol on preventing cardiovascular response and sore throat, hoarseness in the patients with double lumen tube to orotracheal intubation. Methods: 60 selective patients (ASA I - II) scheduled for lung lobectomy were randomly divided into 3 groups, with 20 cases in each group. Lidocaine aerosol (group A) and Saline as a control (group B and group C) were given to spray. After routine induction, the glottis was exposed and 3 press lidocaine aerosol were given in group A, while group B and C were given saline. Patients in group C were received additional 0.5mg/kg of propofol and 1μg /kg of fentanyl intravenously before the exposure of glottis. HR, SBP, DBP, HR*SBP were monitored and recorded at the time points of pre-induction (T0), immediately pre-intubation (T1), 1 min (T2), 3 min (T3), 5min (T4), 10min (T5) after intubation. Cases of sore throat and hoarseness were also recorded at the point of 1h, 6h, 24h postoperation. Results: Compared with T0, values of HR, SBP and RPP at T1 were significantly decreased after inductionP<0.05. Values of HR, SBP, RPP in group B and C were higher than that in group A at T2 and T3P<0.05. SBP was significantly decreased at T4 and T5 in group CP<0.05. Cases of postoperative sore throat and hoarseness in group A were significantly lower than that in group B and CP<0.05. Conclusion: Lidocaine aerosol can effectively suppress cardiovascular responses caused by double lumen tube intubation, decrease the dose of induction drugs, reduce the incidence of postoperative sore throat and hoarseness.