Genetics of Mitochondrial Myopathies
Journal of Genetic Medicine
;
: 20-26, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-83946
ABSTRACT
Mitochondrion is an intracellular organelle with its own genome. Its function in cellular metabolism is indispensable that mitochondrial dysfunction gives rise to multisystemic failure. The manifestation is most prominent with tissues of high energy demand such as muscle and nerve. Mitochondrial myopathies occur not only by mutations in mitochondrial genome, but also by defects in nuclear genes or secondarily by toxic insult on mitochondrial replication. Currently curative treatment modality does not exist and symptomatic treatment remains mainstay. Administration of L-arginine holds great promise according to the recent reports. Advances in mitochondrial RNA import might enable a new therapeutic strategy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Arginine
/
ARN
/
Organites
/
Génome
/
Ophtalmoplégie externe progressive
/
Myopathies mitochondriales
/
Syndrome MERRF
/
Syndrome MELAS
/
Génome mitochondrial
/
Mitochondries
langue:
Anglais
Texte intégral:
Journal of Genetic Medicine
Année:
2013
Type:
Article
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