TNF receptor-associated factor 6 expression in peripheral blood mononuclear cells of patients with primary sjögren's syndrome and its cinical significance / 第二军医大学学报

ABSTRACT

Objeciive To investigative the expressoin of TNF receptor-associated factor 6 (TRAF6) in the peripheral blood mononuclear cells (PBMCs) of primary Sjögren syndrome (pSS) patients and its clinical significance. Methods The expression of TRAF6 mRNA was determined by quantified reverse transceipsional PCR in the PBMCs of 23 pSS patients and 23 heaithy controls. The correlation 0f TRAF6 mRNA level with the laboratory findings, including serum rheumatoid factor (RF), globulin, anli-SSA and anli-SSA antibody, were analyzed by Spearman test. Nine of the pSS patients were followed up and their TRAF6 mRNA expression was detected after glucocorlicoid treatment for 1-2 months. Results The TRAF6 mRNA level in pSS patients was 2. 77 times higher than that in the healthy controls (P< 0. 01). The TRAF6 mRNA level in pSS patients was positively correlated with serum RF (r=0. 45, P = 0. 03) and globidln (r=0. 43, P = 0, 04), but was not assosiated the antibody. TRAF6 mRNA level was decreased by aboijt 50% n the palients who were treated with glucocorlicoids for 1-2 mcmths (P<0. 05). Conclusion TRAF6 n PBMCs is involved in the pathogenesiss of pSS and it may be a potential biomarker for pSS.