Preparation and quality evaluation of dispersible tablets of isoflavonoids from Belamcanda chinensis / 第二军医大学学报

ABSTRACT

Objective: To investigate the preparation technique and quality evaluation of dispersible tablets of isoflavonoids from Belamcanda chinensis. Methods: With the disintegrating time taken as index, the formula of isoflavonoid dispersible tablets was optimized by orthogonal experiment, and the influencing factors were observed. Three batches of samples were made using the optimized prescription, and the quality evaluation was done by examining the disintegration time, dissolution rate, and dispersing uniformity. Results: The optimized formula was A2B2C2. The contents of crospovidone(A), gelling starch(B) and gum arabic(C) were 12%, 14% and 3%, respectively. As crospovidone and gelling starch, the ratios before granulation to after pre-compress were all 21. The products formulated by the optimum techniques disintegrated in 30 s and dissolved in 45 min, which, together with the dispersing uniformity, met the quality criteria of dispersed tablets. Conclusion: The dispersible tablets prepared in this study have a good distribution homogeneity and a higher dissolution rate. The preparation is simple and suitable for industrial production.