Chemical constituents in the mycelia of an acidoduric streptomycetes / 第二军医大学学报

ABSTRACT

Objective: To investigate the chemical constituents in the myceiia of an acidoduric streptomycetes. Methods: Multiple chromatographic methods were used to isolate and purify the constituents, and their chemical structures were identified by NMR, IR, and MS. The anti-inflammatory activities of four compounds were observed in rats with C II -A- induced toe swelling experiments. Results: Four compounds were identified 8-(4-hydroxy-3, 5-di-methoxy phenyl)-2, 3- dimethoxy-1, 6-naphthalenediol (1), 7, 4′-dihydroxy isoflavone (2), 5, 7, 4'-trihydroxyisoflavone (3), and 3, 4, 5-trihydroxybenzoic acid (4). Compound of 2, 3, and 4 could inhibit C II-A-induced toe swelling in rats at 10 mg/(kg • d). Conclusion: Compound 1 is a novel compound, and other compounds have been isolated from the acidoduric Streptosporangium sp. for the first time. Compounds 2,3, and 4 possess anti-inflammatory activities.