Antinociceptive Interactions between Intrathecal Gabapentin and MK801 or NBQX in Rat Formalin Test
Journal of Korean Medical Science
;
: 307-312, 2005.
Article
Dans Anglais
| WPRIM
| ID: wpr-84035
ABSTRACT
Antagonists for spinal N-methyl-D-aspartate (NMDA) and amino-hydroxy-methtyl-isoxazolepropionate (AMPA) receptors are effective in attenuating acute nociception or injury-induced hyperalgesia. The antinociception of spinal gabapentin is developed in injury-induced hyperalgesia without affecting acute nociception. The authors evaluated the effects of intrathecal gabapentin, NMDA antagonist (MK801) and AMPA antagonist (NBQX) in the formalin test which shows injury-induced hyperalgesia as well as acute pain. We further assessed the interactions between gabapentin and either MK801 or NBQX. Male Sprague-Dawley rats were implanted with intrathecal catheters. To evoke pain, 50 microliter of 5% formalin solution was injected into the hindpaw. The interaction was investigated by a fixed dose analysis or an isobolographic analysis. MK801 and NBQX suppressed flinching responses during phase 1 of the formalin test, while gabapentin had little effect on phase 1. All three agents decreased the phase 2 flinching response. A fixed dose analysis in phase 1 showed that gabapentin potentiated the antinociceptive effect of MK801 and NBQX. Isobolographic analysis in phase 2 revealed a synergistic interaction after coadministration of gabapentin-MK801 or gabapentin-NBQX. Correspondingly, spinal gabapentin with NMDA or AMPA antagonist may be useful in managing acute pain and injury-induced hyperalgesia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Quinoxalines
/
Injections rachidiennes
/
Maléate de dizocilpine
/
Rat Sprague-Dawley
/
Récepteurs du N-méthyl-D-aspartate
/
Récepteur de l'AMPA
/
Antagonistes des acides aminés excitateurs
/
Acides cyclohexanecarboxyliques
/
Interactions médicamenteuses
/
Acide gamma-amino-butyrique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2005
Type:
Article
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