Expression of PIAS2 in testis tissues of patients with different pathological types of azoospermia / 第二军医大学学报

ABSTRACT

Objective: To investigate the expression of PIAS2 in the testis tissues of patients with different spermatogenic functions. Methods: Eighty testicular biopsy samples from patients with azoospermia were subjected to pathological diagnosis and were divided into the following groups according to the pathological findings: normal or basically normal spermatogenesis group (n = 40), hypo-spermatogenesis group (HS, n = 20), and sertoli cell-only syndrome group (SCOS, n = 20). Immunohistochemical method (SP) was used to examine the expression of PIAS2 in the testis tissues with different spermatogenic functions. Results: PIAS2 was strongly positive (dark brown) in the spermatogenic cells of different functions. It was weakly positive or absent in the Leydig cells and Sertoli cells. Conclusion: The status of PIAS2 in the testicular tissues is associated with the spermatogenic functions, and it may serve as a potential parameter for predicting of spermatogenic function.