Chemical Constituents with Antihyperlipidemic Activities from Desmodium triquetrum / 中草药·英文版
Chinese Herbal Medicines
;
(4): 324-327, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-842357
ABSTRACT
Objective:
To study the chemical constituents from Desmodium triquetrum and their antihyperlipidemic activities.Methods:
The constituents of D. triquetrum were isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The lipid-lowering effects of the isolates were evaluated in HepG2 cells.Results:
Nine compounds were obtained from the ethanol extract of D. triquetrum and determined to be 6'-. O-cis-p-coumaroyl-3,5-dihydroxyphenyl-β-. D-glucopyranoside (1), tadehaginoside (2), rutin (3), quercetin-3-O-β-. D-glucopyranoside (4), quercetin-3-O-β-. D-galactopyranoside (5), 6-. O-(E)-. p-hydroxy-cinnamoyl-β-glucose (6), 6-. O-(E)-. p-hydroxy-cinnamoyl-α-glucose (7), kaempferol-3-O-β-. D-rutinoside (8), and 3-. O-β-D-galacopyranosyl (6-1)-α-. L-rhamnosyl quercetin (9). Compounds 1 and 2 significantly reduced the intracellular content of total cholesterols and triglycerides.Conclusion:
Compound 1 is a new phenolic compound and exhibits potent anti-hyperlipidemic activity. Additionally, compounds 6 and 7 are isolated from D. triquetrum for the first time.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Herbal Medicines
Année:
2014
Type:
Article
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