Pregnancy outcome comparison between primiparas and multiparas with advanced maternal age / 上海交通大学学报（医学版）

ABSTRACT

Objective:To explore the risk of adverse pregnancy outcomes in the primiparas and the multiparas with advanced maternal age. Methods:Through a retrospective cohort study, 6 129 elderly women who gave birth to a single child from January 2014 to December 2016 in the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine were collected to compare the differences in pregnancy outcomes between the primiparas and the multiparas (parity=2). Logistic regression analysis was used to evaluate the risk of adverse pregnancy outcomes in the two groups of pregnant women. Results:Compared with the multiparas, the primiparas with advanced maternal age had a higher risk of premature rupture of membranes (adjusted OR=1.35, 95% CI 1.18-1.54), preeclampsia/eclampsia (adjusted OR=1.99, 95% CI 1.45-2.73), gestational diabetes mellitus (adjusted OR=1.32, 95% CI 1.15-1.51), small-for-gestation age (adjusted OR=2.49, 95% CI 1.78-3.48), and cesarean section (adjusted OR=1.45, 95% CI 1.30-1.62). The birth weight of infants delivered by the primiparas was slightly lower than that of the multiparas. Conclusion:In the advanced maternal age women, primiparas have a higher risk of adverse perinatal outcomes than multiparas, such as premature rupture of membranes, preeclampsia/eclampsia, gestational diabetes mellitus, small-for-gestation age and cesarean section.