Research progress of role of Pi3k/Akt pathway in mechanism of atypical antipsychotic drugs / 上海交通大学学报（医学版）

ABSTRACT

The alterations of Pi3k/Akt pathway may be critical in the pathogenesis of schizophrenia. Furthermore, atypical antipsychotic drugs can modify Pi3k/Akt pathway, which have been received wide attention. This review mainly focused on four aspects, i.e. metabolic syndrome, changes in immune function, cognitive impairment and neuroprotective effect, and summarized the research progress of role of Pi3k/Akt pathway in the mechanism of atypical antipsychotic drugs.