Roles of TRIM28 in tumorigenesis and embryogenesis / 上海交通大学学报（医学版）

ABSTRACT

TRIM28, known as a kind of macro-molecules, consists of multiple domains and belongs to one of human tripartite motif-containing proteins families. This superfamily contains more than 60 proteins in total and is characterized by four conservative domains, also referred to the RBCC domain, which is a RING (really interesting new gene) finger, two B-boxes (type 1 and type 2) and a leucine zipper coiled-coil region. TRIM28 plays its pivotal roles in transcriptional co-activation or co-repression by interacting directly with transcription factors, within which is a Kruppel-associated box domain (KRAB domain). Moreover, it is critical during the development of embryos, the differentiation of cells and the regulation of cancers.