Molecular mechanisms of atherosclerosis accelerated by hypertriglyceridemia: Research advances / 国际药学研究杂志

ABSTRACT

Recently, the relationship between hypertriglyceridemia (HTG) and atherosclerosis has become the new research focus, as HTG increases the lipids exchange between lipoproteins mediated by cholesteryl ester transfer protein (CETP), increases the concentrations of triglyceride-rich lipoproteins through the apolipoprotein C III and increases the high platelet CD40L expressions. In this paper, we briefly introduced the related drugs and focus on the latest epidemiological survey data and the molecular mechanisms of HTG accelerating atherosclerosis. Our purpose is to further clarify the important role and significance of triglycerides in the development of atherosclerosis, and provide a new theoretical basis for the prevention and treatment of atherosclerotic cardiovascular disease.