Pharmacokinetics and tissue distribution of Chuanhuning emuslion in rats / 国际药学研究杂志

ABSTRACT

Objective To study the pharmacokinetics and tissue distribution of Chuanhuning-emulsion (CHE) in rats. Methods The commercial ordinary Chuanhuning injection was used as the reference (CHR) to evaluate the pharmacokinetics and tissue distribution of CHE. After intravenous administration of CHE or CHR(40 mg/kg) in rats, the concentration of dehydroandrographolide succinate (DAS, the active ingredients of CHE in vivo) was detected by LC-MS/MS. Pharmacokinetic analysis was performed using WinNolin 6. 2. Tissue distribution and targeting were evaluated through tissue concentrations. Results First, a suitable detection method was set up to study the pharmacokinetics of DAS. Second, there was no significant difference between CHR and CHE in the pharmacokinetic parameters. However, the concentrations of DAS in lungs of CHE group were higher than those in CHR group even at 2 h after iv administration of CHE or CHR. Conclusion CHE has a similar pharmacokinetic profile as CHR in rats. Furthermore, the cumulation of DAS in lungs is increased, which illustrates that CHE could enhance DAS targeted in lungs.