Lipophilic small molecular compounds from human placenta / 国际药学研究杂志

ABSTRACT

Objective To nvestigate he ipophilic constituents of human placenta. Methods The compounds were separaed and purified by various column chromatography(silica gel,Sephadex LH-20) and heir structures were established by spectroscopic methods and X-ray diffraction analysis. Rusults Twenty-one compounds were solated from human placenta. Their structures were dentified as cyclo(Leu-Ala) (1),cyclo(Leu-Val) (2),cyclo(Leu-Pro) (3),cyclo(Val-Pro) (4),cyclo(Phe-Leu) (5),caffeine(6), uracil(7), thymine (8), 2'-0-methyluridine (9), 2'-deoxyuridine (10), cholesterol (11), 16a-hydroxyprogesterone (12), 16a-hydroxytestosterone(13),estriol(14),20(fi)-hydroxypregn