A novel immunosuppressant fingolimod: Research advances / 国际药学研究杂志

ABSTRACT

Fingolimod (FTY720), a novel immunosuppressive agent, is synthesized by modification of myriocin (ISP-1) from a raditional Chinese herbal medicine Isaclaria sinclrii. Unlike he traditional immunosuppressive agents, fingolimod exerts immunosuppressive and mmunoregulatory functions mainly hrough nteraction with shhingosine-1-phosphate receptors (SIPR) on he cell surface without affecting activation and proliferation of lymphocytes. This article briefly reviews the effects of fingolimod on he distribution and cytokine production of lymphocytes as well as natural immune cells (dendritic cell, macrophage, natural killer cell and natural killer T cell), suggesting he mmunosuppression and mmune regulation functions of fingolimod n nflammation. Then he atest research progress about the herapeutic application of fingolimod n autoimmune diseases, graft-versus-host diseases and umors, the adverse effects of fingolimod and possible solutions are summarized.