Application of microwave mutagenesis in microorganism breeding for medicinal source strain improvement / 国际药学研究杂志

ABSTRACT

Microwave mutagenesis has become a new physical mutation technique by non-ionizing electromagnetic radiation, which has been used in the breeding of crops, plants and microorganisms, and has revealed bright future development in its application in the microorganism breeding for medicinal source strain improvement for providing high productivity or diverse bioactive mutants. This article reviews bioeffects of microwave, possible mechanisms of microwave mutagenesis, methods of microwave mutation technique together with main factors probably affecting microwave mutagenesis, and research advances in the application of microwave mutagenesis in microorganism breeding for medicinal source strain improvement. Meanwhile, the present research status, advantage and disadvantage, and prospect of this technique are also discussed focusing on its application in the microorganism breeding for medicinal source strain improvement.