N-(2-hydroxypropyl) methacrylamide copolymer-anticancer drugs: Research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
; (6): 174-180, 2010.
Article
de Zh
| WPRIM
| ID: wpr-845947
Bibliothèque responsable:
WPRO
ABSTRACT
The conjugates of polymer with anticancer drug, due to their enhanced permeability and retention effect can accumulate in solid tumors at a much higher concentration than n normal tissues or organs, which results n higher targeting distribution and lower systemic toxicity. As a macromolecule carrier, N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer has many advantages, such as biocompatibility and nonimmunogenicity, so HPMA copolymer-anticancer conjugates has become the focus of large-weight-molecule targeted therapies. Now six HPMA copolymer-anticancer drugs have been evaluated clinically, and many other conjugates are in the stage of preclinical tests. In this paper, research advances in HPMA copolymer-anticancer conjugates are reviewed.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of International Pharmaceutical Research
Année:
2010
Type:
Article