Blood-brain barrier transport of drug-loaded nanoparticle: Research advances / 国际药学研究杂志

ABSTRACT

The blood-brain barrier(BBB) is the basic structure to maintain homoestasis of the central nervous system, which has protective effect on brain tissue, but prevents many drugs into the brain, resulting in the limited clinical application of these drugs. How to effectively deliver the drugs through BBB has become a key step. As a novel drug-loaded carrier, nanoparticle can carry drugs through the BBB and increase the drug concentration in the brain, so as to achieve brain targeted drug delivery. This article briefly reviews recent research advances in drug-loaded nanoparticle and the mechanism of penetrating through BBB into brain tissue.