Therapeutic application of adipose stem cell-free liquid extracts: Skin aging, wound healing, scar recovery and nerve regeneration / 中国组织工程研究

ABSTRACT

BACKGROUND: Adipose stem cell-free liquid extracts include adipose stem cell conditioned medium, adipose stem cell exosomes, because they do not contain cells and have the advantages of being easy to carry, store, and transport, which has gradually become one of the most promising therapies currently. OBJECTIVE: To review the research progress in the therapeutic application of adipose stem cell-free liquid extracts. METHODS: The first author searched the CNKI, Wanfang and PubMed databases for relevant articles published from January 2005 to March 2020. The key words were “adipose stem cell, stromal cell and conditioned medium”, “adipose stem cell, stromal cell and exosomes” in Chinese, and “adipose stem cell, adipose stromal cell and conditioned medium” and “adipose stem cell, adipose stromal cell and exosomes” in English. Repetitive articles and those lacking of originality were eliminated. Totally 123 articles were searched initially, and 62 articles were included in result analysis. RESULTS AND CONCLUSION: Adipose stem cell-free liquid extracts have broad therapeutic potential in a variety of disease areas, such as anti-aging, wound healing, scar recovery, and nerve regeneration. However, the specific mechanism of action is not very clear, and further research is needed.