Application and function of autologous blood concentrate in tissue regeneration / 中国组织工程研究

ABSTRACT

BACKGROUND: Autologous blood concentrates are widely applied in clinical practice. They are easy to prepare, and can promote the regeneration of soft and hard tissues. Their application prospects can be broad in periodontal treatment, oral implant therapy and many other fields. OBJECTIVE: To review the development, biological characteristics and clinical application of autohemoconcentrate. METHODS: The first author searched the related literature published on PubMed, CNKI and Wanfang databases from 2004 to 2019. The key words were “autologous blood concentration, platelet-rich plasma, platelet-rich fibrin” in English, and “blood concentration, platelet-rich plasma, platelet-rich fibrin” in Chinese. The titles and abstracts were selected, and the full text was consulted. Finally, 59 articles were retained for careful reading and analysis. RESULTS AND CONCLUSION: Containing huge amount of platelets and leukocytes, autologous blood concentrate could produce a highly positive effect on the regeneration of soft and hard tissues and the reduction of postoperative inflammatory response. When it is in use alone or in combination with other bone transplantation materials, the effect of bone augmentation is positive. However, the degradation rate is high. How to control its absorption rate requires further study.