Application value of18F-FDG PET/CT in evaluating post-operative recurrence and metastasis of penile squamous cell carcinoma / 肿瘤

ABSTRACT

Objective: To explore the value of fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT imaging in monitoring postoperative recurrence and metastasis of penile squamous cell carcinoma. Methods: A total of 50 patients with penile squamous cell carcinoma received therapy in Peking University Cancer Hospital from May 2011 to June 2017 were collected as the study subjects. The PET/CT imaging was used to monitor the recurrence and metastasis of tumor, while the pathology result and follow-up data were considered as the gold standard. Results: Based on the pathology result and follow-up data,18F-FDG PET/CT imaging results showed 31 of the 50 patients had recurrence and metastases.18F-FDG PET/CT positive imaging was found in 36 patients with 6 false positive cases, and18F-FDG PET/CT negative imaging was found in 14 patients with 1 false negative case. The sensitivity, specificity and accuracy of18F-FDG PET/CT were 96.8%, 68.4% and 86.0%, respectively; the false positive rate and the false negative rate were 31.6% and 3.2%, respecively; the positive predictive value and the negative predictive value were 83.3% and 92.9%, respecively. A total of 60 lesions were detected in 31 patients with recurrence and metastases. There was no significant difference in maximum standard uptake value (SUVmax) among the metastatic tumors of different sites (P = 0.088). The SUVmax had no significant difference between the true positive lymph nodes and the false positive lymph nodes (P = 0.195). The recurrence and metastasis rates of the TNM stage III- patients older than 60 years of age were higher than those of the TNM stage -Ⅱ patients younger than 60 years of age (both P < 0.05). Conclusion: The18F-FDG PET/CT examination has high sensitivity and accuracy for the diagnosis of postoperative recurrence and metastasis of penile squamous cell carcinoma, but there are still some false positive results.