Extranodal nasal type natural killer/T-cell lymphoma with refractory hyponatremia: A case report and literature review / 肿瘤

ABSTRACT

Objective: To improve the understanding of the dilutional hyponatremia caused by syndrome of inappropriate antidiuretic hormone (SIADH) in extranodal nasal type natural killer (NK)/T cell lymphoma. Methods: The clinical manifestations and the diagnosis and treatment process of one case of extranodal nasal type NK/T cell lymphoma with SIADH were reported, and the related literatures were reviewed. Results: A 71 year-old male patient presented with testicular enlargement, multiple rashes with eschar and obstinate hyponatremia as the main features. The results of pelvic MRI examination and the pathological biopsy of skin rash suggested extranodal NK/T cell lymphoma (nasal type) which caused SIADH, excluding other diseases related to hyponatremia. The incidence rate of extranodal nasal type NK/T cell lymphoma was very low; however, it had features of rapid progression and higher mortality rate. Conclusion: The most important treatment of SIADH is etiological treatment. Patients with obvious skin rash, obstinate hyponatremia and testicular enlargement may be suspected of NK/T cell lymphoma. Pathological biopsy should be performed timely to avoid misdiagnosis.