Association between 894G>T polymorphism of nitric oxide synthase 3 (NOS3) gene and genetic susceptibility to prostate cancer: A Meta-analysis / 肿瘤
Tumor
;
(12): 135-140, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-848805
ABSTRACT
Objective:
To evaluate the association between the 894G>T polymorphism of nitric oxide synthase 3 (NOS3) gene and the susceptibility to prostate cancer.Methods:
A computer-based online search was performed by using Cochrane Library, PubMed, EMBase, CNKI (China National Knowledge Infrasrtucture), Wanfang database and VIP database. The case-control studies were selected according to defined inclusion and exclusion criteria. After quality evaluation and data abstraction, a Meta-analysis was performed by using STATA 12.0 software. Odds ratio (OR) of the association between NOS3 894G>T and prostate cancer susceptibility was pooled. Then the subgroup analysis, sensitivity analysis and publication bias test were performed.Results:
A total of 5 case-control studies were eligible for this analysis, including 3 078 cases and 3 677 healthy controls. Meta-analysis showed that NOS3 894G>T polymorphism didn't increase the risk of prostate cancer [TT vs GG, OR = 0.95, 95% confidence interval (CI) 0.80-1.14; TT vs GT, OR = 0.88, 95% CI 0.73-1.05; TT+GT vs GG, OR = 1.07, 95% CI 0.97-1.18; TT vs GG+GT, OR = 0.92, 95% CI 0.77-1.09]. In the subgroup analysis of ethnicity, NOS3 894G>T polymorphism didn't increase the risk of prostate cancer in Europeans (TT vs GG, OR = 0.87, 95% CI 0.73-1.04; TT vs GT, OR = 0.85, 95% CI 0.71-1.02; TT+GT vs GG, OR = 1.00, 95% CI 0.90-1.11; TT vs GG+GT, OR = 0.86, 95% CI 0.72-1.02).Conclusion:
NOS3 894G>T polymorphism is not associated with the prostate cancer susceptibility as well as in Europeans. Copyright © 2014 by TUMOR.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude observationnelle
/
Facteurs de risque
/
Revues systématiques évaluées
langue:
Chinois
Texte intégral:
Tumor
Année:
2014
Type:
Article
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