Advances in research on canonical Wnt signaling pathways in malignant lymphomas / 肿瘤

ABSTRACT

Wnt signaling pathway is an important pathway for regulating the development of embryo and organs. It has been shown to play a key role in proliferation, differentiation, polarity, adhesion and motility of cells. The constitutive activation of canonical Wnt pathway is involved in the pathogenesis of many carcinomas. In recent years, accumulating studies have suggested its association with the pathogenesis of malignant lymphomas. This review summarizes the latest progress in research on canonical Wnt pathway and its role in lymphocyte development and the occurrence of malignant lymphomas, in order to provide the new clues of mechanism for pathogenesis of lymphomas and then disclose new potential therapeutic targets which are based on this pathway. Copyright © 2012 by TUMOR.