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The association of menstruation of breast cancer patients with chemotherapy regimen and aging period / 肿瘤
Tumor ; (12): 999-1002, 2007.
Article de Zh | WPRIM | ID: wpr-849466
Bibliothèque responsable: WPRO
ABSTRACT
Objective: We aimed to study the influence of chemotherapeutic regimens and aging of breast cancer patients on chemotherapy-induced amenorrhea (CIA) and to guide the further selection of drugs for endocrine therapy. Methods: We retrospectively studied the chemotherapy-induced amenorrhea (CIA) of the premenopausal breast cancer patients and compare the difference in CIA between the patients who received different chemotherapies or at different aging periods. Results: One hundred and three women were followed up. The difference in the rate of CIA was not statistically significant between the women who received anthracycline-based chemotherapy and docetaxel-based chemotherapy (70.6% vs 61.1%, P = 0.719). The occurrence rate of CIA was significantly higher in older women (> 45 years) than young women ( ≤45 years, P = 0.001). CIA occurred more lately in young women than old women (P = 0.001). Conclusion: Age is an important factor for the CIA. Chemotherapy has less influence on the menstruation of younger women (≤45 years) and most amenorrhea is reversible. For these patients aromatase inhibitors are not recommended for adjuvant endocrine therapy. The effect of docetaxel on menstruation is not greater than anthracycline.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Tumor Année: 2007 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Tumor Année: 2007 Type: Article