Study of hormones correlated with gastric motility and effect of electroacupuncture in uncomplicated obese subjects / 解放军医学杂志

ABSTRACT

Objective To explore the effects of gastric motility (GM) related hormones on the GM of uncomplicated obese binge eater, and to explore the effect of electroacupuncture on weight loss. MethodsThirty-two obese subjects with habit of immoderate eating and 20 healthy subjects with normal weight were enrolled. Venous blood samples were collected at 800p. m. after an overnight fast and collected again 30min after meal, then stored at -70oCerum ghrelin and GLP-1 were determined with ELISA method and motilin and leptin levels were determined by radioimmunoassay. 30min stimulation of electroacupuncture was performed daily on the obese persons for a week. On the eighth day, blood samples of the obese were collected again. Results Whether before or after meal, serum motilin and leptin levels were higher in obese group than in the control group (P0.05), and serum GLP-1 increased significantly in comparison with those before stimulation (P<0.01) in the obese group. ConclusionElectroacupuncture stimulation gives a certain therapeutic effect on loss of body weight in uncomplicated obese population with immoderate eating by affecting the endocrines related to GM.