Development of andrographolide colon-targeting release pellets based on quality by design (QbD) approach / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 5462-5469, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-850700
ABSTRACT
Objective:
To optimize andrographolide pellet by using a quality by design (QbD) approach.Methods:
Usingthe cumulative in vitro release as evaluation index, the single-factor investigation and hazard analysis were used to study the core and coating process of andrographolide colon-targeting pellets, and the central composite design-response surface method was used to optimize and predict the three key factors of plasticizer dosage, aging time, and coating weight gain.Results:
The optimum coating process parameters were as following plasticizer dosage of 3 g, coating weight gain of 20%, and aging time of 1 h. The process had been verified that the optimal formulation process had a cumulative in vitro release of 6.9% in the acid phase (0.1 mol/L HCl)-buffered salt phase (pH 6.0) and a cumulative in vitro release of more than 90% in the pH 7.2 buffered salt phase.Conclusion:
It is feasible to apply the QbD concept optimization in the study of andrographolide colon-targeting pellets.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
langue:
Chinois
Texte intégral:
Chinese Traditional and Herbal Drugs
Année:
2019
Type:
Article
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