Research strategy of quality markers of Chinese materia medica based on total quantum statistical moment theory / 中草药

ABSTRACT

The quality control of Chinese materia medica (CMM) is the basis for ensuring the safety and effectiveness of clinical medication of traditional Chinese medicine. The whole process of Chinese medicine processing has a great impact on the final quality. The research and determination of the Q-marker of CMM are of great significance to the substance basis research on CMM, the identification of Chinese medicinal materials, the processing of CMM, and the processing of CMM pharmaceutics. The total quantum statistical moment (TQSM) can fully reflect the chromatographic fingerprints information of CMM, with additive, coupling and strong anti-interference. It can be used for qualitative and quantitative analysis of the whole process of CMM, and can also be used to explore the pharmaceutic rule of Chinese medicine compound and its pharmacokinetic process, which can achieve a comprehensive reflection of the quality of CMM and its compound. Through systematic analysis of the research progress of Chinese medicine Q-marker and the principle and application of TQSM, this paper attempts to provide ideas for the research and determination of Chinese medicine quality markers based on TQSM.