Application of metabolomics in antidepressant pharmacological research of Xiaoyao Powder / 中草药

ABSTRACT

Metabolomics, as an important part of systematic biology, is more closely related to phenotype, and has the characteristics of integrity, objectivity, sensitivity and dynamics, which enables it to be rapidly applied and popularized in the research field of traditional Chinese medicine. In this paper, the application of metabolomics in antidepressant pharmacological research, screening of pharmacodynamic markers and development of new antidepressant drugs were summarized. Xiaoyao Powder can achieve the therapeutic effect through the rectifying effect of energy metabolism and intestinal microflora metabolism. Amino acids, sugars, and other substances may be the diagnostic markers of depression or therapeutic markers of Xiaoyao Powder. On the basis of fully exploring the scientific connotation of the antidepressant effect of Xiaoyao Powder, a new antidepressant medicine was created to provide new ideas and explore new approaches for the inheritance and development of the classic formula.