Chemical constituents of alkaloids part of Cephalotaxus hainanensis / 中草药

ABSTRACT

Objective To study the alkaloids constituents from Cephalotaxus hainanensis. Methods The column chromatography Sephadex LH-20 and ODS were used to isolate and purify the compounds of alkaloids part of C. hainanensis. The chemical structures were identified on basis of physicochemical properties and spectral data. Results Thirteen compounds were isolated and identified as cephalotaxine (1), isocephalotaxinone (2), cephalotaxinone (3), cephalezomine G (4), (2R,3S,4S,5S)-2,3-dihydroxycephalotaxane (5), acetylcephalotaxine (6), deoxyharringtonine (7), (R)-fortunine (8), (S)-fortunine (9), isomer of 3-epi-schellhammericine (10), 1,4 (PrINH)2-anthraquinone (11), 2-ethyl-n-hexyl benzoate (12), and β-sitosterol (13). Conclusion Compounds 3-6 and 10-13 are isolated from this plant for the first time.