A Series of Cases of Fukuda Classification Grade IV Tetrodotoxin Poisoning due to Ingestion of Tetrodotoxin from Puffer Fish

ABSTRACT

Ingestion of the eyes and many of the internal organs of puffer fish can result in severe and potentially lethal intoxication, but there is little available information regarding the results of grade IV tetrodotoxin (TTX) intoxication. Thus, we retrospectively reviewed and analyzed the clinical characteristics of ventilator therapy patients and those suffering respiratory failure after ingestion of TTX from puffer fish, who were admitted to our hospital from January 2002 to May 2011. Of the total patients evaluated, we observed seven cases of Fukuda classification grade IV TTX poisoning. All patients were discharged without any complications within 5-26 days after admission.