Research progress on intervention of traditional Chinese medicine on coronary heart disease through mTOR signaling pathway / 中草药

ABSTRACT

The mammalian target of rapamycin (mTOR) signaling pathway has biological functions such as regulation of cell growth, autophagy, proliferation, and apoptosis, and plays an important role in tumor, cardiovascular, and cerebrovascular diseases. In recent years, two pathways of mTOR signaling, AMPK (AMP-dependent protein kinase)/mTOR and Akt (phosphoinositide-3 kinase)/mTOR pathway, have gained increasing attention. This paper mainly reviews the relationship between two pathways of mTOR and development of coronary heart disease, as well as the intervention of traditional Chinese medicine.