Anti-inflammatory mechanism of Shufeng Jiedu Capsules in rat pneumonia model / 中草药

ABSTRACT

Objective To explore the anti-inflammatory mechanism of Shufeng Jiedu Capsules (SJC). Methods The Streptococcus pneumoniae (SP)-induced pneumonia model of rats was used to study the anti-inflammation of SJC. The factors related to inflammatory response from the blood plasma such as leukocyte count and its classification, complement C3, bradykinin (BK), monocyte chemotactic protein (MCP-1), NF-κB, COX-1, COX-2, and bacterial count were measured after the administration of SJC. Results SJC significantly decreased the bacterial count in peripheral blood and BALF, and leukocyte in peripheral blood; It also significantly reduced the levels of NF-κB, MCP-1, BK, and COX-2 in serum. Conclusion SJC has significant sterilization and anti-inflammation effects, which shows significantly therapeutic effect on pneumonia model rats by reducing the levels of NF-κB, MCP-1, BK, and COX-2.