Chemical constituents of Shenkun Yangxue Granules based on UPLC-Q-Orbitrap HRMS / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 4231-4240, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-851683
ABSTRACT
Objective To study the chemical compositions of Shenkun Yangxue Granules. A novel ultra high performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry (UPLC-Q-Orbitrap HRMS) was established to rapidly and accurately recognize the complex chemical constituents of Chinese materia medica. Methods The information of accurate mass in Full-MS and multistage fragment ions was obtained by UPLC-Q-Orbitrap HRMS technology. Chemical constituents were identified by comparing their relative retention times and the mass data with those of reference substances, as well as consulting the reference literature or Chemical Book Network Database. Results Fifty-one compounds were finally identified from Shenkun Yangxue Granules, including the organic acids, flavones, quinones, glycosides, and others. Conclusion The method established in this study can identify various chemical constituents of Shenkun Yangxue Granules rapidly, accurately and systematically. What’s more, our research will lay a sound theoretical foundation and scientific study idea for improving the quality control, bioactive components recognition and further clinical application of this herbal formulation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Traditional and Herbal Drugs
Année:
2018
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS