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Structural modification and anti-inflammatory biological evaluation of monomeric compounds from Aralia elata / 中草药
Chinese Traditional and Herbal Drugs ; (24): 1525-1532, 2018.
Article Dans Chinois | WPRIM | ID: wpr-852064
ABSTRACT

Objective:

Based on structural modification of monomeric compound calenduloside E from Aralia elata, to evaluate anti-inflammatory activity of the analogues.

Methods:

Applying oleanolic acid as starting material, the target compounds were prepared by seven steps reactions and evaluated for anti-inflammatory effects by RAW264. 7 cells in vitro.

Results:

Ten analogues G1-G5 and H1-H5 were synthesized. The structures of the target compounds were identified by spectrum. Pharmacological results showed that all of the compounds had different levels potency of anti-inflammatory effects in cells. In particular, compounds G1-G4 and H1-H3 showed significant anti-inflammatory activity comparing wiht lead compounds.

Conclusion:

The new compounds G1-G5 and H1-H5 which showed potential of anti-inflammatory biological activity, had not been reported in any literatures and deserved further research.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Chinese Traditional and Herbal Drugs Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Chinese Traditional and Herbal Drugs Année: 2018 Type: Article