Study on component compatibility regularity of Chinese material medica in treatment of cardiovascular diseases based on association rules mining / 中草药

ABSTRACT

To reveal the relationship between components and components, components and syndromes based on data mining. Analyzing the component compatibility regularity in treatment of cardiovascular diseases from the component level provides the basis for treating the diseases with multi-component Chinese medicine based on the combination of syndrome and symptom in Chinese medicine clinic. Through the collection and structural processing of the key points in the literature data in recent 20 years, the mining results of Chinese material medica (Chinese medicinal materials/decoction pieces), Chinese patent medicine and related components for the treatmet of cardiovascular diseases were analyzed by association rules mining algorithm. The component compatibilities for treating cardiovascular diseases with a higher correlation were screened out. New component compatibility forms were found. The effective substances and/or possible component compatibility of single herb and Chinese herbal compound were confirmed or speculated. The relationship between components compatibility and diseases, components and syndromes were revealed. Based on association rules mining, it can provide new ideas and methods for component compatibility and optimization, and provide technical support for the research and development of component Chinese medicine.