Correlation of powder particle size and in vitro dissolution rate in Xuejie Sanqi Jiegu Paste based on multi-components determination / 中草药

ABSTRACT

Objective To investigate the relationship between powder particle size and dissolution of Xuejie Sanqi Jiegu Paste (XSJP) in vitro. Methods The particle size of three kinds of XSJP was measured by laser particle size instrument. The hydroxysafflor yellow A, asperosaponin VI, ginsenoside Rg1, ginsenoside Rb1, notoginsenoside R1, dracorhodin were taken as indexes, and the feature of dissolution for the above three kinds of XSJP was examined by grouting method. The correlation between the powders in different particle sizes and their corresponding dissolution was analyzed by software SPSS 17.0. Results The particle size of the three kinds of powders was correlated with the dissolution of index components. The powders in different particle sizes were negatively correlated with the relative cumulative dissolution of hydroxysafflor yellow A, asperosaponin VI, ginsenoside Rg1, ginsenoside Rb1 and notoginsenoside R1. The cumulative dissolution of superfine powder was respectively increased by 6.8%, 16.6%, 6.6%, 6.7%, and 5.4%, while the dracorhodin had no direct correlation. Conclusion There is a correlation between the particle size and dissolution of Chinese medicine with fibre which contains cellular structure.